abstract：:Chronic obstructive pulmonary disease (COPD) is one of the top five major causes of morbidity and mortality worldwide. Despite worldwide health care efforts, costs, and medical research, COPD figures demonstrate a continuously increasing tendency in mortality. This is contrary to other top causes of death, such as neo...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Hillas G,Perlikos F,Tzanakis N

更新日期：2016-07-13 00:00:00

abstract：BACKGROUND:COPD is a major cause of death and morbidity worldwide, and is characterized by persistent airflow obstruction. The evaluation of obstruction is critically dependent on sensitive methods for lung-function testing. A wide body of knowledge has been accumulated in recent years showing that these methods have b...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Lopes AJ,de Melo PL

更新日期：2016-07-11 00:00:00

abstract：BACKGROUND:The chronic obstructive pulmonary disease (COPD) assessment test (CAT) is a short questionnaire that has facilitated health status measurements in subjects with COPD. However, it remains controversial as to whether the CAT can be used as a suitable substitute for the St George's Respiratory Questionnaire (SG...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Morishita-Katsu M,Nishimura K,Taniguchi H,Kimura T,Kondoh Y,Kataoka K,Ogawa T,Watanabe F,Arizono S,Nishiyama O,Nakayasu K,Imaizumi K,Hasegawa Y

更新日期：2016-07-07 00:00:00

abstract：BACKGROUND:Little is known regarding the relationship between balance impairments and physical activity in COPD. There has been no study investigating the relationship between balance and objectively measured physical activity. Here we investigated the association between balance and physical activity measured by an ac...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Iwakura M,Okura K,Shibata K,Kawagoshi A,Sugawara K,Takahashi H,Shioya T

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:The use of chlorofluorocarbons (CFCs) has contributed to the depletion of the stratospheric ozone layer resulting in serious health concerns. Ipratropium bromide/salbutamol sulphate CFC-pressurized metered-dose inhalers (IB/SAL-CFC pMDI) have been in widespread use for many years without any apparent ill con...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Bhattacharya A,Bhargava S,Singh V,Talwar D,Whig J,Rebello J,Purandare S,Gogtay J

更新日期：2016-06-30 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Chronic obstructive pulmonary disease (COPD) is one of the most debilitating somatic diseases, having anxiety and depression frequently as comorbidities. The coping style, the way in which the subject manages to control the difficult and stressful situations of life, can influence its evolutio...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Papava I,Oancea C,Enatescu VR,Bredicean AC,Dehelean L,Romosan RS,Timar B

更新日期：2016-06-20 00:00:00

abstract：INTRODUCTION:COPD exacerbation negatively impacts the patient's quality of life and lung function, increases mortality, and increases socioeconomic costs. In a real-world setting, the majority of patients with COPD have mild-to-moderate airflow limitation. Therefore, it is important to evaluate COPD exacerbation in pat...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Kim JK,Lee SH,Lee BH,Lee CY,Kim do J,Min KH,Kim SK,Yoo KH,Jung KS,Hwang YI

更新日期：2016-06-16 00:00:00

abstract：INTRODUCTION:Guidelines recommendations for the treatment of COPD are poorly followed. This could be related to the complexity of classification and treatment algorithms. The purpose of this study was to validate a simpler dyspnea-based treatment algorithm for inhaled pharmacotherapy in stable COPD, comparing its conco...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Cabrera C,Casanova C,Martín Y,Mirabal V,Sánchez Mdel C,Álvarez F,Juliá G,Cabrera-Navarro P,García-Bello MÁ,Marín JM,de-Torres JP,Divo M,Celli B

更新日期：2016-06-08 00:00:00

abstract：BACKGROUND:This study was conducted in order to investigate the differences in the respiratory physiology of patients with chronic obstructive pulmonary disease (COPD), asthma-COPD overlap syndrome (ACOS), and asthma with airflow limitation (asthma FL(+)). METHODS:The medical records for a series of all stable patient...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Kitaguchi Y,Yasuo M,Hanaoka M

更新日期：2016-05-09 00:00:00

abstract：PURPOSE:There are still evidence gaps on the prevalence of airflow limitation in Japan. The purpose of this survey was to estimate the prevalence of airflow limitation among healthy subjects in Japan and to show what proportion of subjects with airflow limitation had been diagnosed with chronic obstructive pulmonary di...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Omori H,Kaise T,Suzuki T,Hagan G

更新日期：2016-04-22 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity, mortality, and health care expenditure worldwide. Relaxation of airway smooth muscle with inhaled bronchodilators is the cornerstone of treatment for stable COPD, with inhaled corticosteroids reserved for those with a history of exacerbation...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Cohen JS,Miles MC,Donohue JF,Ohar JA

更新日期：2016-04-15 00:00:00

abstract：BACKGROUND:Previous studies have relied on international spirometry criteria to diagnose COPD in patients with lung cancer without considering the effect lung cancer might have on spirometric results. The aim of this study was to examine the prevalence of COPD and emphysema at the time of primary lung cancer diagnosis ...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Ytterstad E,Moe PC,Hjalmarsen A

更新日期：2016-03-23 00:00:00

abstract：:Exacerbations of COPD represent an important medical and health care problem. Certain susceptible patients suffer recurrent exacerbations and as a consequence have a poorer prognosis. The effects of bronchial infection, either acute or chronic, and of the inflammation characteristic of the disease itself raise the que...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Santos S,Marin A,Serra-Batlles J,de la Rosa D,Solanes I,Pomares X,López-Sánchez M,Muñoz-Esquerre M,Miravitlles M

更新日期：2016-03-11 00:00:00

abstract：OBJECTIVES:Emphysema is one of the prognostic factors for rapid lung function decline in patients with COPD, but the impact of incidentally detected emphysema on population without spirometric abnormalities has not been evaluated. This study aimed to determine whether emphysema detected upon computed tomography (CT) sc...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Koo HK,Jin KN,Kim DK,Chung HS,Lee CH

更新日期：2016-01-29 00:00:00

abstract：BACKGROUND:Limited mobility is a risk factor for developing chronic obstructive pulmonary disease (COPD)-related disabilities. Little is known about the validity of the Short Physical Performance Battery (SPPB) for identifying mobility limitations in patients with COPD. OBJECTIVE:To determine the clinical validity of ...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Bernabeu-Mora R,Medina-Mirapeix F,Llamazares-Herrán E,García-Guillamón G,Giménez-Giménez LM,Sánchez-Nieto JM

更新日期：2015-12-03 00:00:00

abstract：:Patients with chronic obstructive pulmonary disease (COPD) are often at high risk of early death. Identification of prognostic biomarkers for COPD may aid in improving their survival by providing early strengthened therapy for high-risk patients. In the present study, we investigated the prognostic role of hyperuricem...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Zhang X,Liu L,Liang R,Jin S

更新日期：2015-11-26 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD), a respiratory disease characterized by a progressive decline in lung function, is considered to be a leading cause of morbidity and mortality. Long-acting inhaled bronchodilators, such as long-acting β2 agonists (LABAs) or long-acting muscarinic antagonists (LAMAs), are th...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Ramadan WH,Kabbara WK,El Khoury GM,Al Assir SA

更新日期：2015-10-30 00:00:00

abstract：OBJECTIVE:Comorbidities are characteristic of COPD. However, little is known about the secondary manifestations of COPD in the gastrointestinal tract. Therefore, we aimed to explore the long-term effects of gastrectomy in patients with spirometry-defined COPD or those at risk of COPD. PARTICIPANTS:Subjects included 87...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Saito H,Nomura K,Abe S,Motegi T,Ishii T,Hattori K,Kusunoki Y,Gemma A,Kida K

更新日期：2015-10-29 00:00:00

abstract：:COPD is a chronic inflammatory disease of the lungs associated with an abnormal inflammatory response to noxious particles, the most prevalent of which is cigarette smoke. Studies have demonstrated that cigarette smoking is associated with activation of the bone marrow, and chronic smoking can lead to the inflammatory...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Carlson AA,Smith EA,Reid DJ

更新日期：2015-10-22 00:00:00

abstract：:COPD is a common complex disease characterized by progressive airflow limitation. Several genome-wide association studies (GWASs) have discovered genes that are associated with COPD. Recently, candidate genes for COPD identified by GWASs include CHRNA3/5 (cholinergic nicotine receptor alpha 3/5), IREB2 (iron regulator...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Kim WJ,Lee SD

更新日期：2015-10-19 00:00:00

abstract：BACKGROUND:Dietary antioxidants have been suggested to have protective role against chronic obstructive pulmonary disease (COPD), but few prospective studies examined this relationship. The prospective study was conducted to evaluate the effect of dietary antioxidants on COPD risk and lung function in the Korean popula...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Joshi P,Kim WJ,Lee SA

更新日期：2015-10-08 00:00:00

abstract：BACKGROUND:COPD is one of the most common chronic diseases, and more and more farmers who were frequently exposed to greenhouse environments were diagnosed with COPD. However, little information is available on the prevalence of COPD among the greenhouse farmers. This study was conducted to assess the prevalence of COP...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Liu S,Ren Y,Wen D,Chen Y,Chen D,Li L,Zhang X,Zhang Y,Fu S,Li Z,Xia S,Wang D,Chen H,Zhao J,Wang X

更新日期：2015-10-01 00:00:00

abstract：:The aim of the study was to assess the budgetary impact of funding smoking-cessation drugs in COPD patients in Spain. A hybrid model (cohort and Markov) was developed for a 5-year time horizon. Only approved cessation drugs (varenicline, bupropion, and nicotine replacement therapy) were considered. Irrespective of the...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Jiménez-Ruiz CA,Solano-Reina S,Signes-Costa J,de Higes-Martinez E,Granda-Orive JI,Lorza-Blasco JJ,Riesco-Miranda JA,Altet-Gomez N,Barrueco M,Oyagüez I,Rejas J,SESEPARAR’s Integrated Tobacco Research Program.

更新日期：2015-09-24 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The overprescription of inhaled corticosteroids (ICS) in the current Global Initiative for Chronic Obstructive Lung Disease (GOLD) group A and B patients with chronic obstructive pulmonary disease (COPD) is not uncommon in clinical practice. The aim of this study was to explore the factors asso...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Wei YF,Kuo PH,Tsai YH,Tao CW,Cheng SL,Lee CH,Wu YK,Chen NH,Hsu WH,Hsu JY,Lin MS,Wang CC

更新日期：2015-09-14 00:00:00

abstract：BACKGROUND:Exercise intolerance is a major issue affecting many people with COPD. Six-minute walking distance (6MWD) is a widely used indicator of exercise capacity in patients with COPD. The process is strenuous and time-consuming, especially for patients who have muscle wasting. Anthropometric indicators that reflect...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Ho SC,Hsu MF,Kuo HP,Wang JY,Chen LF,Lee KY,Chuang HC

更新日期：2015-09-08 00:00:00

abstract：BACKGROUND:Krasnoyarsk region is a territory with the widespread risk factors for chronic obstructive pulmonary disease (COPD) such as tobacco smoke, air pollution, and occupational exposure. An assessment of COPD prevalence based on medical diagnosis statistics underestimates the true COPD prevalence. This study aims ...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Artyukhov IP,Arshukova IL,Dobretsova EA,Dugina TA,Shulmin AV,Demko IV

更新日期：2015-09-02 00:00:00

abstract：BACKGROUND:Previous studies have documented that C-reactive protein (CRP) levels are increased in stable COPD patients. However, most studies have also shown that higher CRP levels are observed in patients with comorbidities like diabetes mellitus and cardiovascular disease. We aimed to investigate if CRP levels are in...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Silva DR,Gazzana MB,Knorst MM

更新日期：2015-08-31 00:00:00

abstract：BACKGROUND:Assessment of dyspnea in COPD patients relies in clinical practice on the modified Medical Research Council (mMRC) scale, whereas the Baseline Dyspnea Index (BDI) is mainly used in clinical trials. Little is known on the correspondence between the two methods. METHODS:Cross-sectional analysis was carried ou...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Perez T,Burgel PR,Paillasseur JL,Caillaud D,Deslée G,Chanez P,Roche N,INITIATIVES BPCO Scientific Committee.

更新日期：2015-08-18 00:00:00

abstract：PURPOSE:Endobronchial valve (EBV) therapy is increasingly being seen as a therapeutic option for advanced emphysema, but its clinical utility in Asian populations, who may have different phenotypes to other ethnic populations, has not been assessed. PATIENTS AND METHODS:This prospective open-label single-arm clinical ...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Park TS,Hong Y,Lee JS,Oh SY,Lee SM,Kim N,Seo JB,Oh YM,Lee SD,Lee SW

更新日期：2015-07-29 00:00:00

abstract：BACKGROUND:The purpose of this study was to assess the relationship of smoking duration with respiratory symptoms and history of chronic obstructive pulmonary disease (COPD) in the South Carolina Behavioral Risk Factor Surveillance System survey in 2012. METHODS:Data from 4,135 adults aged ≥45 years with a smoking his...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Liu Y,Pleasants RA,Croft JB,Wheaton AG,Heidari K,Malarcher AM,Ohar JA,Kraft M,Mannino DM,Strange C

更新日期：2015-07-21 00:00:00

abstract：BACKGROUND:Although chronic obstructive pulmonary disease (COPD) is closely associated with gastroesophageal reflux disease (GERD), the clinical significance of laryngopharyngeal reflux (LPR) is not fully understood in COPD. METHODS:Prospective cohorts were established among 118 patients with COPD from March 2013 to J...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Jung YH,Lee DY,Kim DW,Park SS,Heo EY,Chung HS,Kim DK

更新日期：2015-07-15 00:00:00

abstract：BACKGROUND:Presence of chronic obstructive pulmonary disease (COPD) in heart failure (HF) has prognostic and therapeutic implications. Exact prevalence estimates are lacking because most previous studies estimated the prevalence of COPD among HF patients while unstable and in the presence of pulmonary congestion. METH...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Valk MJ,Broekhuizen BD,Mosterd A,Zuithoff NP,Hoes AW,Rutten FH

更新日期：2015-06-26 00:00:00

abstract：BACKGROUND:We investigated whether a relationship between small airways dysfunction and bronchodilator responsiveness exists in patients with chronic obstructive pulmonary disease (COPD). METHODS:We studied 100 (20 female; mean age: 68±10 years) patients with COPD (forced expiratory volume in 1 second [FEV1]: 55% pred...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Pisi R,Aiello M,Zanini A,Tzani P,Paleari D,Marangio E,Spanevello A,Nicolini G,Chetta A

更新日期：2015-06-19 00:00:00

abstract：OBJECTIVE:To investigate the gene-expression profile of chronic obstructive pulmonary disease (COPD) patients and explore the possible therapeutic targets. METHODS:The microarray raw dataset GSE29133, including three COPD samples and three normal samples, was obtained from Gene Expression Omnibus. After data preproces...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Wei L,Xu D,Qian Y,Huang G,Ma W,Liu F,Shen Y,Wang Z,Li L,Zhang S,Chen Y

更新日期：2015-06-10 00:00:00

abstract：BACKGROUND:Whereas the epidemiological association between lung cancer and chronic obstructive pulmonary disease (COPD), a chronic inflammatory respiratory disease, is well known, limited studies have examined the association between lung cancer and non-cystic fibrosis bronchiectasis, a representative chronic airway in...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Kim YW,Jin KN,Heo EY,Park SS,Chung HS,Kim DK

更新日期：2015-05-04 00:00:00

abstract：BACKGROUND:Management of chronic incurable diseases such as chronic obstructive pulmonary disease (COPD) and asthma is difficult. Incorporation of patient preferences is widely encouraged. PURPOSE:To summarize original research articles determining patient preference in moderate-to-severe disease. METHODS:Acceptable ...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Bereza BG,Troelsgaard Nielsen A,Valgardsson S,Hemels ME,Einarson TR

更新日期：2015-04-08 00:00:00

abstract：BACKGROUND:Long-acting inhaled bronchodilators, including anticholinergic tiotropium, are recommended for the maintenance therapy of chronic obstructive pulmonary disease (COPD). It has been shown in a number of studies that treatment with tiotropium alleviates symptoms, improves exercise tolerance, health status, and ...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Jahnz-Różyk K,Szepiel P

更新日期：2015-03-18 00:00:00

abstract：BACKGROUND:In addition to smoking, acute exacerbations are considered to be a contributing factor to progression of chronic obstructive pulmonary disease (COPD). However, these findings come from studies including active smokers, while results in ex-smokers are scarce and contradictory. The purpose of this study was to...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Dreyse J,Díaz O,Repetto PB,Morales A,Saldías F,Lisboa C

更新日期：2015-03-10 00:00:00

abstract：BACKGROUND:Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory condition, and progresses with acute exacerbations. (AE). During AE, levels of acute phase reactants such as C-reactive protein (CRP) and inflammatory cells in the circulation increase. Soluble urokinase-type plasminogen activator recepto...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Gumus A,Altintas N,Cinarka H,Kirbas A,Hazıroglu M,Karatas M,Sahin U

更新日期：2015-02-13 00:00:00

abstract：BACKGROUND:Glycopyrronium is a once-daily (od) long-acting muscarinic antagonist for the maintenance treatment of chronic obstructive pulmonary disease (COPD). The GLOW7 study evaluated the efficacy and safety of od glycopyrronium 50 μg in predominantly Chinese patients with moderate-to-severe COPD. METHODS:In this 26...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Wang C,Sun T,Huang Y,Humphries M,Bai L,Li L,Wang Q,Kho P,Firth R,D'Andrea P

更新日期：2015-01-05 00:00:00